YTHDF2 Antikörper

Produktnummer ABIN5705079

Produktdetails anti-YTHDF2 Antikörper

Target: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YTHDF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: YTH domain family, member 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:5000,IF:1:10-1:100,IP:1:200-1:2000,IHC:1:20-1:200

Kommentare:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09573( YTHDF2 Antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu YTHDF2

Target: YTHDF2 (YTH Domain Family, Member 2 (YTHDF2))

Andere Bezeichnung: YTHDF2 (YTHDF2 Produkte)

Synonyme: MGC82537 antikoerper, HGRG8 antikoerper, NY-REN-2 antikoerper, YTH N(6)-methyladenosine RNA binding protein 2 L homeolog antikoerper, YTH N6-methyladenosine RNA binding protein 2 antikoerper, ythdf2.L antikoerper, YTHDF2 antikoerper

Hintergrund: Synonyms:CLL associated antigen KW 14, HGRG8, NY REN 2, YTH domain family protein 2, YTH domain family, member 2, YTHDF2 Background:Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, and regulates mRNA stability(PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies(P-bodies), leading to mRNA degradation(PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation(PubMed:26458103).

Molekulargewicht: 61kDa

Gen-ID: 51441

UniProt: Q9Y5A9