JMY Antikörper
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- Target Alle JMY Antikörper anzeigen
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser JMY Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Immunogen
- junction mediating and regulatory protein, p53 cofactor
- Isotyp
- IgG
- Top Product
- Discover our top product JMY Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04443( JMY Antibody) at dilution of 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- Andere Bezeichnung
- JMY (JMY Produkte)
- Synonyme
- WHDC1L3 antikoerper, junction mediating and regulatory protein, p53 cofactor antikoerper, junction-mediating and regulatory protein antikoerper, JMY antikoerper, jmy antikoerper, Jmy antikoerper
- Hintergrund
- Synonyms:JMY, WHDC1L3 Background:Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location(By similarity).
- Molekulargewicht
- 111 kDa
- Gen-ID
- 133746
- UniProt
- Q8N9B5
- Pathways
- Regulation of Actin Filament Polymerization
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