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JMY Antikörper

JMY Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5704810
  • Target Alle JMY Antikörper anzeigen
    JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
    Reaktivität
    • 45
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 42
    • 4
    Kaninchen
    Klonalität
    • 42
    • 3
    Polyklonal
    Konjugat
    • 25
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser JMY Antikörper ist unkonjugiert
    Applikation
    • 31
    • 28
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Immunogen
    junction mediating and regulatory protein, p53 cofactor
    Isotyp
    IgG
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04443( JMY Antibody) at dilution of 1:1000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze / thaw cycles.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
    Andere Bezeichnung
    JMY (JMY Produkte)
    Synonyme
    WHDC1L3 antikoerper, junction mediating and regulatory protein, p53 cofactor antikoerper, junction-mediating and regulatory protein antikoerper, JMY antikoerper, jmy antikoerper, Jmy antikoerper
    Hintergrund
    Synonyms:JMY, WHDC1L3 Background:Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location(By similarity).
    Molekulargewicht
    111 kDa
    Gen-ID
    133746
    UniProt
    Q8N9B5
    Pathways
    Regulation of Actin Filament Polymerization
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