PMEPA1 Antikörper

Produktnummer ABIN5704584

Produktdetails anti-PMEPA1 Antikörper

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PMEPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Immunogen: prostate transmembrane protein, androgen induced 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

L02 cells were subjected to SDS PAGE followed by western blot with FNab06569( PMEPA1 Antibody) at dilution of 1:600

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu PMEPA1

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Andere Bezeichnung: PMEPA1 (PMEPA1 Produkte)

Synonyme: Tmepai antikoerper, PMEPA1 antikoerper, TMEPAI antikoerper, zgc:92731 antikoerper, tmepai antikoerper, STAG1 antikoerper, 2210418I02Rik antikoerper, AW455466 antikoerper, Erg1.2 antikoerper, N4wbp4 antikoerper, Stag1 antikoerper, prostate transmembrane protein, androgen induced 1 antikoerper, prostate transmembrane protein, androgen induced 1 L homeolog antikoerper, Pmepa1 antikoerper, PMEPA1 antikoerper, pmepa1 antikoerper, pmepa1.L antikoerper

Hintergrund: Synonyms:STAG1, TMEPAI Background:Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal(PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor(AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4(PubMed:18703514).

Gen-ID: 56937

UniProt: Q969W9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway