VPS4B Antikörper

Produktnummer ABIN5701702

Produktdetails anti-VPS4B Antikörper

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS4B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Immunogen: vacuolar protein sorting 4 homolog B (S. cerevisiae)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB :1:500-1:5000,IP:1:500-1:5000,IF:1:10-1:100

Kommentare:

Y79 cells were subjected to SDS PAGE followed by western blot with FNab09446(VPS4B antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu VPS4B

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Andere Bezeichnung: VPS4B (vps4b Produkte)

Synonyme: zgc:63682 antikoerper, vps4a antikoerper, SKD1 antikoerper, SKD1B antikoerper, VPS4-2 antikoerper, 8030489C12Rik antikoerper, Skd1 antikoerper, vacuolar protein sorting 4 homolog B antikoerper, vacuolar protein sorting 4 homolog B S homeolog antikoerper, vacuolar protein sorting 4b homolog B (S. cerevisiae) antikoerper, vacuolar protein sorting 4 homolog B (S. cerevisiae) antikoerper, vacuolar protein sorting 4B antikoerper, Vps4b antikoerper, vps4b.S antikoerper, vps4b antikoerper, VPS4B antikoerper

Hintergrund: Synonyms:MIG1, Protein SKD1, SKD1, VPS4 2, VPS42, VPS4B Background:Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).

Molekulargewicht: 49kDa

Gen-ID: 9525

UniProt: O75351

Pathways: Microtubule Dynamics, CXCR4-mediated Signaling Events