VPS4B Antikörper (AA 1-117)

Produktnummer ABIN7175320

Produktdetails anti-VPS4B Antikörper

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Bindungsspezifität: AA 1-117

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS4B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 4B protein (1-117AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VPS4B

Target: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Andere Bezeichnung: VPS4B (vps4b Produkte)

Synonyme: zgc:63682 antikoerper, vps4a antikoerper, SKD1 antikoerper, SKD1B antikoerper, VPS4-2 antikoerper, 8030489C12Rik antikoerper, Skd1 antikoerper, vacuolar protein sorting 4 homolog B antikoerper, vacuolar protein sorting 4 homolog B S homeolog antikoerper, vacuolar protein sorting 4b homolog B (S. cerevisiae) antikoerper, vacuolar protein sorting 4 homolog B (S. cerevisiae) antikoerper, vacuolar protein sorting 4B antikoerper, Vps4b antikoerper, vps4b.S antikoerper, vps4b antikoerper, VPS4B antikoerper

Hintergrund:

Background: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: 8030489C12Rik antibody, Cell migration inducing 1 antibody, Cell migration-inducing gene 1 protein antibody, MGC116271 antibody, MIG1 antibody, Protein SKD1 antibody, Skd1 antibody, SKD1B antibody, Suppressor of K(+) transport growth defect 1 antibody, Suppressor of K+ transport defect 1 antibody, Vacuolar protein sorting 4 homolog B (S. cerevisiae) antibody, Vacuolar protein sorting 4 homolog B antibody, Vacuolar protein sorting 4b antibody, Vacuolar protein sorting-associated protein 4B antibody, Vacuolar protein sorting-associating protein 4B antibody, VPS4 2 antibody, VPS42 antibody, Vps4b antibody, VPS4B_HUMAN antibody

UniProt: O75351

Pathways: Microtubule Dynamics, CXCR4-mediated Signaling Events