MARK4 Antikörper

Produktnummer ABIN5701080

Produktdetails anti-MARK4 Antikörper

Target: MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARK4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Immunogen: MAP/microtubule affinity-regulating kinase 4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu MARK4

Target: MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))

Andere Bezeichnung: MARK4 (MARK4 Produkte)

Synonyme: MARK4 antikoerper, MARK4L antikoerper, MARK4S antikoerper, MARKL1 antikoerper, MARKL1L antikoerper, PAR-1D antikoerper, 2410090P21Rik antikoerper, C79806 antikoerper, Markl1 antikoerper, microtubule affinity regulating kinase 4 antikoerper, MAP/microtubule affinity regulating kinase 4 antikoerper, MARK4 antikoerper, Mark4 antikoerper

Hintergrund: Synonyms:KIAA1860, MARKL1 Background:Serine/threonine-protein kinase(PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT(PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4(PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles(PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly(PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro(PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint(PubMed:25123532). Reduces neuronal cell survival(PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate(By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway(By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation(PubMed:23184942).

Gen-ID: 57787

UniProt: Q96L34