Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

MARK4 Antikörper (Internal Region)

MARK4 Reaktivität: Human, Maus ELISA, WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6263134
  • Target Alle MARK4 Antikörper anzeigen
    MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))
    Bindungsspezifität
    • 16
    • 15
    • 13
    • 8
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 48
    • 38
    • 3
    Human, Maus
    Wirt
    • 60
    • 1
    • 1
    Kaninchen
    Klonalität
    • 61
    • 1
    Polyklonal
    Konjugat
    • 23
    • 6
    • 6
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MARK4 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 41
    • 13
    • 13
    • 11
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    MARK4 Antibody detects endogenous levels of total MARK4.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MARK4, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product MARK4 Primärantikörper
  • Applikationshinweise
    IF/ICC 1:100-1:500, WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))
    Andere Bezeichnung
    MARK4 (MARK4 Produkte)
    Synonyme
    MARK4 antikoerper, MARK4L antikoerper, MARK4S antikoerper, MARKL1 antikoerper, MARKL1L antikoerper, PAR-1D antikoerper, 2410090P21Rik antikoerper, C79806 antikoerper, Markl1 antikoerper, microtubule affinity regulating kinase 4 antikoerper, MAP/microtubule affinity regulating kinase 4 antikoerper, MARK4 antikoerper, Mark4 antikoerper
    Hintergrund

    Description: Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).

    Gene: MARK4

    Molekulargewicht
    82kDa
    Gen-ID
    57787
    UniProt
    Q96L34
Sie sind hier:
Kundenservice