UBE2O Antikörper

Produktnummer ABIN5700803

Produktdetails anti-UBE2O Antikörper

Target: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2O Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: ubiquitin-conjugating enzyme E2O

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB : 1:200-1:2000

Kommentare:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab09181(UBE2O antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu UBE2O

Target: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Andere Bezeichnung: UBE2O (UBE2O Produkte)

Synonyme: e2-230k antikoerper, E2-230K antikoerper, 9630022H21 antikoerper, B230113M03Rik antikoerper, mKIAA1734 antikoerper, RGD1310297 antikoerper, ubiquitin conjugating enzyme E2 O antikoerper, ubiquitin-conjugating enzyme E2O antikoerper, UBE2O antikoerper, ube2o antikoerper, Ube2o antikoerper

Hintergrund: Synonyms:E2-230K, FLJ12878, KIAA1734, UBE2O, Ubiquitin carrier protein O, Ubiquitin protein ligase O Background:E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins(PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity(PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis(PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal(NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location(PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853).

Molekulargewicht: 18kDa

Gen-ID: 63893

UniProt: Q9C0C9