UBE2O Antikörper (AA 1073-1292)

Produktnummer ABIN6149817

Produktdetails anti-UBE2O Antikörper

Target: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Bindungsspezifität: AA 1073-1292

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2O Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Sequenz: LVNEPYYNEA GFDSDRGLQE GYENSRCYNE MALIRVVQSM TQLVRRPPEV FEQEIRQHFS TGGWRLVNRI ESWLETHALL EKAQALPNGV PKASSSPEPP AVAELSDSGQ QEPEDGGPAP GEASQGSDSE GGAQGLASAS RDHTDQTSET APDASVPPSV KPKKRRKSYR SFLPEKSGYP DIGFPLFPLS KGFIKSIRGV LTQFRAALLE AGMPECTEDK

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1073-1292 of human UBE2O (NP_071349.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:4000,IF,1:50 - 1:200,IP,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu UBE2O

Target: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Andere Bezeichnung: UBE2O (UBE2O Produkte)

Synonyme: e2-230k antikoerper, E2-230K antikoerper, 9630022H21 antikoerper, B230113M03Rik antikoerper, mKIAA1734 antikoerper, RGD1310297 antikoerper, ubiquitin conjugating enzyme E2 O antikoerper, ubiquitin-conjugating enzyme E2O antikoerper, UBE2O antikoerper, ube2o antikoerper, Ube2o antikoerper

Hintergrund: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.,UBE2O,E2-230K,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,UBE2O

Molekulargewicht: 141 kDa

Gen-ID: 63893

UniProt: Q9C0C9