PRKG1 Antikörper

Produktnummer ABIN5700509

Produktdetails anti-PRKG1 Antikörper

Target: PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: protein kinase, cGMP-dependent, type I

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu PRKG1

Target: PRKG1 (Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Andere Bezeichnung: PRKG1 (PRKG1 Produkte)

Synonyme: prkg1 antikoerper, zgc:63955 antikoerper, Pkgi antikoerper, cGk1 antikoerper, 1 antikoerper, PKG antikoerper, PRKG1B antikoerper, PRKGR1B antikoerper, cGK antikoerper, cGK 1 antikoerper, cGK1 antikoerper, cGKI antikoerper, cGKI-BETA antikoerper, cGKI-alpha antikoerper, CGKI antikoerper, cGKI-beta antikoerper, AW125416 antikoerper, Gm19690 antikoerper, Prkg1b antikoerper, Prkgr1b antikoerper, Prkg1beta antikoerper, protein kinase, cGMP-dependent, type Ia antikoerper, protein kinase, cGMP-dependent, type I antikoerper, protein kinase, cGMP-dependent, type 1 antikoerper, prkg1a antikoerper, PRKG1 antikoerper, prkg1 antikoerper, Prkg1 antikoerper

Hintergrund: Synonyms:PRKG1B, PRKGR1A, PRKGR1B Background:Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Gen-ID: 5592

UniProt: Q13976