Spastin Antikörper

Produktnummer ABIN5698478

Produktdetails anti-Spastin Antikörper

Target: Spastin (SPAST)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Spastin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: spastin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu Spastin

Target: Spastin (SPAST)

Andere Bezeichnung: SPAST (SPAST Produkte)

Synonyme: CG5977 antikoerper, D-spastin antikoerper, Dmel\\CG5977 antikoerper, Dspastin antikoerper, Spas antikoerper, zgc:85952 antikoerper, SPAST antikoerper, spg4 antikoerper, LOC100224472 antikoerper, ADPSP antikoerper, FSP2 antikoerper, SPG4 antikoerper, Spg4 antikoerper, mKIAA1083 antikoerper, spastin antikoerper, spastin S homeolog antikoerper, spas antikoerper, spast antikoerper, SPAST antikoerper, Spast antikoerper, spast.S antikoerper

Hintergrund: Synonyms:Kiaa1083, Spg4 Background:ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated(PubMed:19141076 PubMed:20530212). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold(By similarity). Severing activity is not dependent on tubulin acetylation or detyrosination(By similarity). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation(By similarity). It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia(By similarity). SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex(By similarity). Recruited at the midbody, probably by IST1, and participates to membrane fission during abscission together with the ESCRT-III complex(By similarity). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase(By similarity). Required for membrane traffic from the endoplasmic reticulum(ER) to the Golgi and endosome recycling(By similarity). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing(By similarity). Probably plays a role in axon growth and the formation of axonal branches(PubMed:18234839). Isoform 1: Involved in lipid metabolism by regulating the size and distribution of lipid droplets.

Gen-ID: 50850

UniProt: Q9QYY8

Pathways: Microtubule Dynamics, M Phase, Regulation of Cell Size