BRD7 Antikörper
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- Target Alle BRD7 Antikörper anzeigen
- BRD7 (Bromodomain Containing 7 (BRD7))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser BRD7 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- bromodomain containing 7
- Isotyp
- IgG
- Top Product
- Discover our top product BRD7 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab00948(BRD7 antibody) at dilution of 1:500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze / thaw cycles.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- BRD7 (Bromodomain Containing 7 (BRD7))
- Andere Bezeichnung
- BRD7 (BRD7 Produkte)
- Synonyme
- zgc:66347 antikoerper, wu:fc95f02 antikoerper, MGC79478 antikoerper, BRD7 antikoerper, BP75 antikoerper, CELTIX1 antikoerper, NAG4 antikoerper, Ptpn13ip antikoerper, bromodomain containing 7 L homeolog antikoerper, bromodomain containing 7 antikoerper, brd7.L antikoerper, brd7 antikoerper, BRD7 antikoerper, Brd7 antikoerper
- Hintergrund
- Synonyms:BP75, CELTIX1 Background:Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR(By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9'(H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
- Molekulargewicht
- 70-74 kDa
- Gen-ID
- 29117
- UniProt
- Q9NPI1
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