BRD7 Antikörper (AA 387-418)

Produktnummer ABIN6242212

Der Kaninchen Polyklonal anti-BRD7 Antikörper (Klon RB43270) (ABIN6242212) detektiert spezifisch BRD7 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für BRD7 Antikörper (AA 387-418) (ABIN6242212)

Target: BRD7 (Bromodomain Containing 7 (BRD7))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB43270

Produktdetails anti-BRD7 Antikörper

Bindungsspezifität: AA 387-418

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MOUSE Brd7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 387-418 amino acids from the Central region of human MOUSE Brd7.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu BRD7

Target: BRD7 (Bromodomain Containing 7 (BRD7))

Andere Bezeichnung: Brd7

Hintergrund: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24- mediated activation of transcriptional activation by AR.

Molekulargewicht: 74000

UniProt: O88665