BBS1 Antikörper

Produktnummer ABIN5697174

Produktdetails anti-BBS1 Antikörper

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BBS1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Immunogen: Bardet-Biedl syndrome 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu BBS1

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Andere Bezeichnung: BBS1 (BBS1 Produkte)

Synonyme: im:7144669 antikoerper, bbs2l2 antikoerper, BBS1 antikoerper, DKFZp468B1612 antikoerper, BBS2L2 antikoerper, AI451249 antikoerper, D19Ertd609e antikoerper, Bardet-Biedl syndrome 1 antikoerper, bardet-biedl syndrome 1 antikoerper, Bardet-Biedl syndrome 1 (human) antikoerper, BBS1 antikoerper, bbs1 antikoerper, Bbs1 antikoerper

Hintergrund: Synonyms:Bardet Biedl syndrome 1, BBS1, BBS2 like protein 2, BBS2L2 Background:The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Molekulargewicht: 65 kDa

Gen-ID: 582

UniProt: Q8NFJ9

Pathways: Hedgehog Signalweg