CD147 Antikörper (AA 138-323) (DyLight 488)

Produktnummer ABIN7354487

Produktdetails anti-CD147 Antikörper (DyLight 488)

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Bindungsspezifität: AA 138-323

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD147 Antikörper ist konjugiert mit DyLight 488

Applikation: Flow Cytometry (FACS)

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG Polyclonal Anti-Human CD147/Emmprin Antibody DyLight® 488 Conjugated, Flow Validated.

Immunogen: E.coli-derived human CD147/Emmprin recombinant protein (Position: E138-A323). Human CD147/Emmprin shares 51.1% and 51.9% amino acid (aa) sequence identity with mouse and rat CD147/Emmprin, respectively.

Anwendungsinformationen

Applikationshinweise:

Application Details: Flow Cytometry, 1-3 μg/1x10⁶ cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: At 2-8°C for one year. Protect from light. Do not freeze.

Referenzen für anti-CD147 Antikörper (DyLight 488) (ABIN7354487)

Zhang, Yang, Liu, Liu, Teng, Zhang, Yin, Liu et al.: "iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of ..." in: Oncology letters, Vol. 14, Issue 3, pp. 3734-3740, (2017) (PubMed).

Xiao, Zhao, Shen, Liang, Chen: "Overexpression of CD147 is associated with poor prognosis, tumor cell migration and ERK signaling pathway activation in hepatocellular carcinoma." in: Experimental and therapeutic medicine, Vol. 14, Issue 3, pp. 2637-2642, (2017) (PubMed).

Lu, Lv, Kim, Ha, Kim: "Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma." in: Oncology letters, Vol. 5, Issue 1, pp. 201-207, (2012) (PubMed).

Details zu CD147

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Andere Bezeichnung: BSG (BSG Produkte)

Synonyme: EMMPRIN antikoerper, RPE7 antikoerper, 5F7 antikoerper, CD147 antikoerper, M6 antikoerper, OK antikoerper, TCSF antikoerper, AI115436 antikoerper, AI325119 antikoerper, HT-7 antikoerper, 5A11 antikoerper, CE9 antikoerper, HT7 antikoerper, Ox47R antikoerper, basignin antikoerper, wu:fb26a05 antikoerper, wu:fo98e12 antikoerper, bsg antikoerper, prso03 antikoerper, basigin (Ok blood group) antikoerper, basigin antikoerper, basigin (Ok blood group) S homeolog antikoerper, BSG antikoerper, Bsg antikoerper, bsg antikoerper, bsg.S antikoerper

Hintergrund:

Synonyms: Basigin, 5F7, Collagenase stimulatory factor, Extracellular matrix metalloproteinase inducer, EMMPRIN, Leukocyte activation antigen M6, OK blood group antigen, Tumor cell-derived collagenase stimulatory factor, TCSF, CD147, BSG, UNQ6505/PRO21383

Tissue Specificity: Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Background: Emmprin, extracellular matrix metalloproteinase inducer, also known as Emmprin (BSG) or cluster of differentiation 147 (CD147) is a protein that in humans is encoded by the Emmprin gene. The human BSG gene is mapped to 19p13.3. This protein is a determinant for the Ok blood group system. BSG has been shown to be an essential receptor on red blood cells for the malaria parasite. It is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily, it plays fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development. BSG is thought also to play a role in intercellular recognition. It also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. BSG is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins. It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes.

UniProt: P35613

Pathways: S100 Proteine