Neuroserpin Antikörper

Produktnummer ABIN5690556

Produktdetails anti-Neuroserpin Antikörper

Target: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuroserpin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hNeuroserpin (human Neuroserpin). Human Neuroserpin specific antibody was purified by affinity chromatography employing immobilized hNeuroserpin matrix.

Anwendungsinformationen

Applikationshinweise: ELISA:
Indirect:
To detect hNeuroserpin by indirect ELISA (using 100 μ,L/well antibody solution) a concentration of 0.5 - 2.0 μ,g/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeuroserpin.

Sandwich
To detect hNeuroserpin by sandwich ELISA (using 100 μ,L/well antibody solution) a concentration of 0.5 - 2.0 μ,g/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with our biotinylated Anti-Human Neuroserpin as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeuroserpin.

Western Blot:
To detect hNeuroserpin by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 μ,g/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hNeuroserpin is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Lagerung: -20 °C

Informationen zur Lagerung: Neuroserpin antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. Avoid repeated freeze-thaw cycles.

Details zu Neuroserpin

Target: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Andere Bezeichnung: Neuroserpin (SERPINI1 Produkte)

Synonyme: PI12 antikoerper, neuroserpin antikoerper, AI837402 antikoerper, Ns antikoerper, PI-12 antikoerper, Spi17 antikoerper, CG9453 antikoerper, Dmel\\CG9453 antikoerper, Serp2 antikoerper, Sp4 antikoerper, Spn4 antikoerper, Spn4A antikoerper, dSerp2 antikoerper, sp4 antikoerper, spn4 antikoerper, raPIT5a antikoerper, SERPINI1 antikoerper, pi12 antikoerper, serpini1l antikoerper, si:ch211-167c22.4 antikoerper, serpin family I member 1 antikoerper, serine (or cysteine) peptidase inhibitor, clade I, member 1 antikoerper, Serpin 42Da antikoerper, serpin peptidase inhibitor, clade I (neuroserpin), member 1 antikoerper, serpin family I member 1 L homeolog antikoerper, SERPINI1 antikoerper, Serpini1 antikoerper, Spn42Da antikoerper, serpini1 antikoerper, serpini1.L antikoerper

Hintergrund: Neuroserpin is a member of the serpin superfamily and is predominantly expressed by neurons of the developing and adult brain. This serpin is secreted from axonal growth cones of the CNS and PNS where it inhibits the enzyme tissue plasminogen activator. The expression pattern of neuroserpin and its in vivo inhibitory activity implicate this serpin in regulating axonal growth, reducing seizure activity, controlling damage in cerebral infarction and regulating emotional behaviour and memory. Four different mutations have been described in the human neuroserpin gene that promote neuroserpin abnormal polymerization, giving rise to intraneuronal inclusion bodies and a new form of dementia called Familial Encephalopathy with Neuroserpin Inclusion Bodies.

Gen-ID: 5274

UniProt: Q99574

Pathways: Regulation of Hormone Metabolic Process