HES5 Antikörper (N-Term)
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- Target Alle HES5 Antikörper anzeigen
- HES5 (Hairy and Enhancer of Split 5 (HES5))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser HES5 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Spezifität
- HES5 antibody is human, mouse and rat reactive. At least two isoforms of HES5 are known to exist, this antibody will detect both isoforms.
- Aufreinigung
- HES5 antibody is affinity chromatography purified via peptide column.
- Immunogen
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HES5 antibody was raised against a 19 amino acid peptide near the amino terminus of human HES5.
The immunogen is located within the first 50 amino acids of HES5. - Isotyp
- IgG
- Top Product
- Discover our top product HES5 Primärantikörper
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- Applikationshinweise
- HES5 antibody can be used for detection of HES5 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- HES5 antibody is supplied in PBS containing 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- HES5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- Target
- HES5 (Hairy and Enhancer of Split 5 (HES5))
- Andere Bezeichnung
- HES5 (HES5 Produkte)
- Synonyme
- fk51a02 antikoerper, her15 antikoerper, hes5 antikoerper, wu:fk51a02 antikoerper, zgc:136520 antikoerper, bHLHb38 antikoerper, hairy and enhancer of split-related 15, tandem duplicate 1 antikoerper, hes family bHLH transcription factor 5 antikoerper, hairy and enhancer of split 5 (Drosophila) antikoerper, transcription factor HES-5-like antikoerper, her15.1 antikoerper, HES5 antikoerper, hes5 antikoerper, LOC100221262 antikoerper, LOC100226434 antikoerper, Hes5 antikoerper
- Hintergrund
- HES5 is a member of the HES family of transcriptional repressors, which are the mammalian homologs of the Drosophila Hairy and Enhancer of Split and contain basic Helix-loop-helix (bHLH) and Orange domains (1). The HES5 gene is a downstream target of the Notch signaling pathway and its expression is downregulated during human cartilage differentiation (2). HES5 can directly repress transcription of the E3 ligase FBW7-beta, creating a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions (3).
- Molekulargewicht
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Predicted: 18 kDa
Observed: 17 kDa - Gen-ID
- 388585
- NCBI Accession
- NP_001010926
- UniProt
- Q5TA89
- Pathways
- Stem Cell Maintenance, Tube Formation
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