ABL1/2 Antikörper (pTyr393, pTyr429)

Produktnummer ABIN5689742

Produktdetails anti-ABL1/2 Antikörper

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Bindungsspezifität: pTyr393, pTyr429

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABL1/2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Immunogen: ABL1/2 (phospho-Tyr393/429) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y (p) -T-A) derived from Human ABL1/2.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu ABL1/2

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Andere Bezeichnung: ABL1 / 2 (ABL1/ABL2 Produkte)

Synonyme: CABL antikoerper, ABLL antikoerper, cb272 antikoerper, ABL proto-oncogene 2, non-receptor tyrosine kinase antikoerper, c-abl oncogene 2, non-receptor tyrosine kinase antikoerper, ABL2 antikoerper, abl2 antikoerper

Hintergrund: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Molekulargewicht: 210 kDa

Gen-ID: 25, 27

NCBI Accession: NP_005148, NP_001129472

UniProt: P00519, P42684