ABL1/2 Antikörper (AA 391-395)

Produktnummer ABIN363102

Produktdetails anti-ABL1/2 Antikörper

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Bindungsspezifität: AA 391-395

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABL1/2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Spezifität: The antibody detects endogenous levels of total ABL1/2 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen. Specificity/Sensitivity ABL1/2 (Ab-393/429) Antibody detects endogenous levels of total ABL1/2 protein.

Immunogen: Peptide sequence around AA 391-395, 427-431 (D-T-Y-T-A) derived from ABL1, 2 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu ABL1/2

Target: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Andere Bezeichnung: ABL1/2 (ABL1/ABL2 Produkte)

Synonyme: CABL antikoerper, ABLL antikoerper, cb272 antikoerper, ABL proto-oncogene 2, non-receptor tyrosine kinase antikoerper, c-abl oncogene 2, non-receptor tyrosine kinase antikoerper, ABL2 antikoerper, abl2 antikoerper

Hintergrund: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Molekulargewicht: 210 kDa

NCBI Accession: NP_001129, NP_005148

UniProt: P42684