MGEA5 Antikörper (AA 236-269)

Produktnummer ABIN5647928

Produktdetails anti-MGEA5 Antikörper

Target: MGEA5 (Meningioma Expressed Antigen 5 (Hyaluronidase) (MGEA5))

Bindungsspezifität: AA 236-269

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MGEA5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität (Details): Expected species reactivity: Mouse,Rat

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 236-269 from human MGEA5 was used as the immunogen for the MGEA5 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the MGEA5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. WB: 1:1000-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the MGEA5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu MGEA5

Target: MGEA5 (Meningioma Expressed Antigen 5 (Hyaluronidase) (MGEA5))

Andere Bezeichnung: MGEA5 (MGEA5 Produkte)

Synonyme: MEA5 antikoerper, NCOAT antikoerper, OGA antikoerper, 2810009A20Rik antikoerper, 4833427O07Rik antikoerper, 5830447M11Rik antikoerper, AA408215 antikoerper, Hy5 antikoerper, Ncoat antikoerper, mKIAA0679 antikoerper, O-GLCNACASE antikoerper, cytochrome c oxidase subunit VIc antikoerper, meningioma expressed antigen 5 (hyaluronidase) antikoerper, COX6C antikoerper, MGEA5 antikoerper, Mgea5 antikoerper

Hintergrund: Isoform 1 (Cytoplasmic): Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:< a href=http://www.uniprot.org/citations/11148210 target=_blank>11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:< a href=http://www.uniprot.org/citations/24088714 target=_blank>24088714).

Isoform 3 (Nuclear): Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. [UniProt]

UniProt: O60502

Pathways: Positive Regulation of Peptide Hormone Secretion, Regulation of Carbohydrate Metabolic Process