BLM Antikörper (Internal Region, pSer186)

Produktnummer ABIN5596802

Produktdetails anti-BLM Antikörper

Target: BLM (Bloom Syndrome RecQ Like Helicase (BLM))

Bindungsspezifität: Internal Region, pSer186

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BLM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): A BLAST analysis was used to suggest cross-reactivity with human based on 100% sequence homology. Cross-reactivity with BLM pS186 from other sources has not been determined.

Aufreinigung: Anti-BLM pS186 was affinity purified from monospecific antiserum by immunoaffinity chromatography and is directed against the phosphorylated form of human S186 residue.

Immunogen:

Immunogen: Anti-BLM pS186 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the internal region of human Bloom syndrome protein.

Immunogen Type: Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Application Note: Anti-BLM pS186 antibody is useful for ELISA, Immunohistochemistry, and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~159 kDa corresponding to the appropriate cell lysate or extract.

Western Blot Dilution: 1 μg/mL

ELISA Dilution: 1: 10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.66 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 30 % Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu BLM

Target: BLM (Bloom Syndrome RecQ Like Helicase (BLM))

Andere Bezeichnung: BLM (BLM Produkte)

Synonyme: BS antikoerper, RECQ2 antikoerper, RECQL2 antikoerper, RECQL3 antikoerper, blm-A antikoerper, xBLM antikoerper, ORF1 antikoerper, Bloom syndrome RecQ like helicase antikoerper, Bloom syndrome RecQ like helicase S homeolog antikoerper, Bloom syndrome, RecQ like helicase antikoerper, BLM antikoerper, blm.S antikoerper, Blm antikoerper

Hintergrund:

Synonyms: DNA helicase, RecQ-like type 2, RECQ2, RECQL3, Bloom syndrome protein

Background: BLM pS186 product is a member of the RecQ helicase protein family. The protein contains 1417 amino acids, including one ATP binding site, one DEAH box, and two putative nuclear localization signals, as well as phosphorylation sites. BLS protein is known to associate and be phosphorylated by the ATR (ataxia telangiectasia, rad3+) protein, in response to genetic stress. The Bloom's syndrome gene product is thought to play a role in the etiology of two major human health problems, each of which is a very common complication of Bloom's syndrome, namely cancer and diabetes. Anti-BLM pS186 antibody is ideal for researchers interested in Epigenetics and Nuclear Signaling or DNA Damage & Repair research.

Gene Name: BLM

Pathways: DNA Reparatur