KDM5D Antikörper (C-Term)

Produktnummer ABIN5541915

Produktdetails anti-KDM5D Antikörper

Target: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Bindungsspezifität: AA 1248-1539, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM5D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects Human JARID1D. Other species not tested.

Aufreinigung: Protein A Chromatography

Immunogen: Highly pure (> 95%) recombinant Human JARID1D (Leu1248-Leu1539) fused to a C-terminal His-tag (6x His) derived from E. coli (Cat.-No AR60001PU-N)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 1-5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purification: Protein A Chromatography

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu KDM5D

Target: KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))

Andere Bezeichnung: jarid1d (KDM5D Produkte)

Synonyme: JARID1D antikoerper, Jarid1d antikoerper, DKFZp468I1010 antikoerper, HY antikoerper, HYA antikoerper, SMCY antikoerper, Smcy antikoerper, lysine demethylase 5D antikoerper, lysine (K)-specific demethylase 5D antikoerper, lysine demethylase 5C antikoerper, KDM5D antikoerper, Kdm5d antikoerper, KDM5C antikoerper

Hintergrund: H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.

Pathways: Warburg Effekt