MARCH1 Antikörper (AA 163-191)

Produktnummer ABIN5538686

Produktdetails anti-MARCH1 Antikörper

Target: MARCH1 (Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1))

Bindungsspezifität: AA 163-191

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MARCH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MARCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human MARCH1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu MARCH1

Target: MARCH1 (Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1))

Andere Bezeichnung: MARCH1 (MARCH1 Produkte)

Synonyme: MARCH-I antikoerper, RNF171 antikoerper, 2900024D24Rik antikoerper, BB085186 antikoerper, RGD1305148 antikoerper, MARCH1 antikoerper, DKFZp459K1250 antikoerper, membrane associated ring-CH-type finger 1 antikoerper, membrane-associated ring finger (C3HC4) 1 antikoerper, MARCH1 antikoerper, March1 antikoerper

Hintergrund: MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266], Thibodeau et al., 2008 [PubMed 18389477], De Gassart et al., 2008 [PubMed 18305173]).

Molekulargewicht: 32 kDa

Gen-ID: 55016

UniProt: Q8TCQ1