MARCH1 Antikörper (C-Term)
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- Target Alle MARCH1 Antikörper anzeigen
- MARCH1 (Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MARCH1 Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- MARCH1 Antibody detects endogenous levels of total MARCH1.
- Homologie
- Rabbit,Chicken
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human MARCH1, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
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- Applikationshinweise
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- MARCH1 (Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1))
- Andere Bezeichnung
- MARCH1 (MARCH1 Produkte)
- Synonyme
- MARCH-I antikoerper, RNF171 antikoerper, 2900024D24Rik antikoerper, BB085186 antikoerper, RGD1305148 antikoerper, MARCH1 antikoerper, DKFZp459K1250 antikoerper, membrane associated ring-CH-type finger 1 antikoerper, membrane-associated ring finger (C3HC4) 1 antikoerper, MARCH1 antikoerper, March1 antikoerper
- Hintergrund
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Description: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
Gene: 1-Mar
- Molekulargewicht
- 32 kDa
- Gen-ID
- 55016
- UniProt
- Q8TCQ1
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