BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143) Antikörper

Produktnummer ABIN5536292

Produktdetails

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Bindungsspezifität: AA 116-143

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-143 amino acids from the Central region of human HSPC142.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For IHC-P starting dilution is: 1:50~100

For WB starting dilution is: 1:1000

For FACS starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Antigendetails

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Andere Bezeichnung: HSPC142 (BABAM1 Produkte)

Synonyme: merit40 antikoerper, nba1 antikoerper, zgc:100909 antikoerper, c19orf62 antikoerper, C19orf62 antikoerper, MERIT40 antikoerper, NBA1 antikoerper, C7H19orf62 antikoerper, 5430437P03Rik antikoerper, Merit40 antikoerper, BRISC and BRCA1 A complex member 1 antikoerper, BRISC and BRCA1 A complex member 1 L homeolog antikoerper, babam1 antikoerper, BABAM1 antikoerper, babam1.L antikoerper, Babam1 antikoerper

Hintergrund: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.

Molekulargewicht: 37 kDa

Gen-ID: 29086

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus