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BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 9-37), (N-Term) Antikörper

BABAM1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB20467 unconjugated
Produktnummer ABIN652513
  • Target Alle BRISC and BRCA1 A Complex Member 1 (BABAM1) Antikörper anzeigen
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Bindungsspezifität
    • 9
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 9-37, N-Term
    Reaktivität
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 21
    • 4
    • 1
    Kaninchen
    Klonalität
    • 24
    • 2
    Polyklonal
    Konjugat
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    Unkonjugiert
    Applikation
    • 23
    • 16
    • 13
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B, Zf
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142.
    Klon
    RB20467
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product BABAM1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Andere Bezeichnung
    HSPC142 (BABAM1 Produkte)
    Synonyme
    merit40 antikoerper, nba1 antikoerper, zgc:100909 antikoerper, c19orf62 antikoerper, C19orf62 antikoerper, MERIT40 antikoerper, NBA1 antikoerper, C7H19orf62 antikoerper, 5430437P03Rik antikoerper, Merit40 antikoerper, BRISC and BRCA1 A complex member 1 antikoerper, BRISC and BRCA1 A complex member 1 L homeolog antikoerper, babam1 antikoerper, BABAM1 antikoerper, babam1.L antikoerper, Babam1 antikoerper
    Hintergrund
    HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component
    Molekulargewicht
    36560
    Gen-ID
    29086
    NCBI Accession
    NP_001028721, NP_054892
    UniProt
    Q9NWV8
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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