p107 Antikörper (C-Term)

Produktnummer ABIN5534582

Produktdetails anti-p107 Antikörper

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Bindungsspezifität: AA 1007-1035, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p107 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1007-1035 amino acids from the C-terminal region of human RBL1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu p107

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Andere Bezeichnung: RBL1 (RBL1 Produkte)

Synonyme: p107 antikoerper, prb1 antikoerper, fj58e06 antikoerper, wu:fj58e06 antikoerper, CP107 antikoerper, PRB1 antikoerper, AW547426 antikoerper, retinoblastoma-like 1 L homeolog antikoerper, RB transcriptional corepressor like 1 antikoerper, retinoblastoma-like 1 (p107) antikoerper, retinoblastoma-like 1 antikoerper, rbl1.L antikoerper, RBL1 antikoerper, rbl1 antikoerper, Rbl1 antikoerper

Hintergrund: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 121 kDa

Gen-ID: 5933

UniProt: P28749

Pathways: Zellzyklus, Mitotic G1-G1/S Phases