This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CPSF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human CPSF4.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
CPSF4
(Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
cpsf30 antikoerper, nar antikoerper, neb1 antikoerper, 30kDa antikoerper, C79664 antikoerper, CPSF30 antikoerper, NAR antikoerper, NEB1 antikoerper, cleavage and polyadenylation specific factor 4 antikoerper, cleavage and polyadenylation specific factor 4, 30kDa antikoerper, cleavage and polyadenylation specific factor 4 S homeolog antikoerper, CPSF4 antikoerper, Cpsf4 antikoerper, LOC733099 antikoerper, LOC100360200 antikoerper, cpsf4.S antikoerper, cpsf4 antikoerper
Hintergrund
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.