TBP Antikörper (C-Term)

Produktnummer ABIN5532231

Produktdetails anti-TBP Antikörper

Target: TBP (TATA Box Binding Protein (TBP))

Bindungsspezifität: AA 301-330, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This TBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-330 amino acids from the C-terminal region of human TBP.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For IF starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TBP

Target: TBP (TATA Box Binding Protein (TBP))

Andere Bezeichnung: TBP (TBP Produkte)

Synonyme: GTF2D antikoerper, GTF2D1 antikoerper, HDL4 antikoerper, SCA17 antikoerper, TFIID antikoerper, Gtf2d antikoerper, fd20h06 antikoerper, si:zc101n13.2 antikoerper, wu:fd20h06 antikoerper, zgc:66213 antikoerper, TBP1 antikoerper, TBP antikoerper, tbp antikoerper, CG9874 antikoerper, Dmel\\CG9874 antikoerper, RBP antikoerper, TBP38 antikoerper, TFIIDtau antikoerper, TfIID antikoerper, dTBP antikoerper, dTFIID antikoerper, dTbp antikoerper, dtbp antikoerper, gtf2d antikoerper, gtf2d1 antikoerper, sca17 antikoerper, tfiid antikoerper, tfiidtau antikoerper, xtbp antikoerper, tbp-a antikoerper, tbp-b antikoerper, TATA-box binding protein antikoerper, TATA box binding protein antikoerper, TATA binding protein antikoerper, TATA-box binding protein L homeolog antikoerper, TATA-box-binding protein antikoerper, TATA-box binding protein S homeolog antikoerper, TBP antikoerper, Tbp antikoerper, tbp antikoerper, tbp.L antikoerper, tbp.S antikoerper

Hintergrund: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.

Molekulargewicht: 38 kDa

Gen-ID: 6908

UniProt: P20226

Pathways: WNT Signalweg