TNNT3 Antikörper (C-Term)

Produktnummer ABIN5531203

Produktdetails anti-TNNT3 Antikörper

Target: TNNT3 (Fast Skeletal Troponin T (TNNT3))

Bindungsspezifität: AA 217-245, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNNT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TNNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the C-terminal region of human TNNT3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TNNT3

Target: TNNT3 (Fast Skeletal Troponin T (TNNT3))

Andere Bezeichnung: TNNT3 (TNNT3 Produkte)

Synonyme: fTnT antikoerper, tnnt3a antikoerper, TNTF antikoerper, TnTf antikoerper, Tnt antikoerper, Tnnt3 antikoerper, troponin T3, fast skeletal type antikoerper, troponin T3, skeletal, fast antikoerper, troponin T3, fast skeletal type S homeolog antikoerper, troponin T type 3 (skeletal, fast) antikoerper, troponin T1, slow skeletal type antikoerper, TNNT3 antikoerper, Tnnt3 antikoerper, tnnt3.S antikoerper, TNNT1 antikoerper

Hintergrund: The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein, also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B).

Molekulargewicht: 32 kDa

Gen-ID: 7140

UniProt: P45378