TNNT3 Produkte
(Fast Skeletal Troponin T (TNNT3))
Kategorien
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein\; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009].
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Ausgewählte TNNT3 Kategorien
TNNT3 Antikörper
High quality antibodies with extensive validation data.
TNNT3 ELISA Kits
Reliable ELISA kits for a wide range of species.
TNNT3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TNNT3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN563217
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC, ICC, IF
Validierungen
- (2)
Kat. Nr.
ABIN6257189
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Chicken, Human, Quail
Applikation
WB, ELISA, IHC, IHC (p), IHC (fro)
Validierungen
- (2)
Kat. Nr.
ABIN462336
Menge
50 μg
Datenblatt
Datenblatt
Empfohlene TNNT3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6963595
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6970896
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6970897
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TNNT3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1323292
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN3074520
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN3130583
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TNNT3 Produkten
: "Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice." in: Aging cell, Vol. 15, Issue 3, pp. 488-98, (2016) (PubMed).: "Hypothyroidism and its rapid correction alter cardiac remodeling." in: PLoS ONE, Vol. 9, Issue 10, pp. e109753, (2014) (PubMed).
: "Troponin T nuclear localization and its role in aging skeletal muscle." in: Age (Dordrecht, Netherlands), Vol. 35, Issue 2, pp. 353-70, (2013) (PubMed).
: "Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis." in: Cytoskeleton (Hoboken, N.J.), Vol. 70, Issue 3, pp. 134-47, (2013) (PubMed).
: "Proteome dynamics during contractile and metabolic differentiation of bovine foetal muscle." in: Animal : an international journal of animal bioscience, Vol. 3, Issue 7, pp. 980-1000, (2012) (PubMed).
: "A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus." in: European journal of medical genetics, Vol. 54, Issue 3, pp. 351-3, (2011) (PubMed).
Synonyme und alternative Namen zu TNNT3
troponin T3, fast skeletal type (TNNT3), troponin T3, skeletal, fast (Tnnt3), troponin T3, fast skeletal type S homeolog (tnnt3.S), troponin T3, fast skeletal type (Tnnt3), troponin T type 3 (skeletal, fast) (TNNT3), troponin T1, slow skeletal type (TNNT1), fTnT, Tnnt3, tnnt3a, Tnt, TNTF, TnTfBezeichner auf Proteinebene für TNNT3
- troponin T variant TnTx7-e16
- troponin T, fast skeletal muscle isoforms
- troponin T3, skeletal, fast
- fast skeletal muscle troponin T
- fast skeletal muscle troponin T3
- skeletal muscle fast-twitch TnT
- tnTf
- troponin T, fast skeletal muscle
- beta TnTF
- beta-TnTF
- fTnT
- troponin-T3, skeletal, fast
- troponin T fast skeletal muscle type
- fast skeletal troponin T beta-1 isoform
- skeletal troponin T alpha-1 isoform
- Fast skeletal muscle troponin T
- Troponin T, fast skeletal muscle
- fetal troponin T 1
- fetal troponin T 2
- troponin T 2f
- troponin T 2fa
- troponin T 4f
- troponin T1f
- troponin T type 1 (skeletal, slow)
- troponin T, slow skeletal muscle
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