DKC1 Antikörper (AA 185-213)

Produktnummer ABIN5531012

Produktdetails anti-DKC1 Antikörper

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Bindungsspezifität: AA 185-213

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DKC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DKC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human DKC1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For IF starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu DKC1

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Andere Bezeichnung: DKC1 (DKC1 Produkte)

Synonyme: CBF5 antikoerper, DKC antikoerper, DKCX antikoerper, NAP57 antikoerper, NOLA4 antikoerper, XAP101 antikoerper, dyskerin antikoerper, fv62a07 antikoerper, wu:fa28f10 antikoerper, wu:fc87a02 antikoerper, wu:fi24a05 antikoerper, wu:fv62a07 antikoerper, zgc:110395 antikoerper, DKC1 antikoerper, cbf5 antikoerper, dkc antikoerper, nap57 antikoerper, nola4 antikoerper, xap101 antikoerper, BC068171 antikoerper, Nap57 antikoerper, AtCBF5 antikoerper, AtNAP57 antikoerper, homologue of NAP57 antikoerper, dyskerin pseudouridine synthase 1 antikoerper, microRNA 664b antikoerper, dyskeratosis congenita 1, dyskerin antikoerper, dyskeratosis congenita 1, dyskerin L homeolog antikoerper, homologue of NAP57 antikoerper, DKC1 antikoerper, MIR664B antikoerper, dkc1 antikoerper, dkc1.L antikoerper, Dkc1 antikoerper, NAP57 antikoerper

Hintergrund: DKC1 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases.

Molekulargewicht: 58 kDa

Gen-ID: 1736

UniProt: O60832

Pathways: Telomere Maintenance