SNRPN Antikörper (N-Term)

Produktnummer ABIN5517959

Produktdetails anti-SNRPN Antikörper

Target: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNRPN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF

Produktmerkmale: This is a rabbit polyclonal antibody against SMN. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SMN

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SNRPN

Target: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Andere Bezeichnung: SMN (SNRPN Produkte)

Synonyme: SNRB' antikoerper, SNRPB' antikoerper, Snrpn antikoerper, zgc:77315 antikoerper, HCERN3 antikoerper, PWCR antikoerper, RT-LI antikoerper, SM-D antikoerper, SMN antikoerper, SNRNP-N antikoerper, SNURF-SNRPN antikoerper, sm-N antikoerper, 2410045I01Rik antikoerper, Peg4 antikoerper, Pwcr1 antikoerper, FE 294 antikoerper, FE 294 psi antikoerper, FE294 antikoerper, FE294 psi antikoerper, SNURF antikoerper, SNRPN antikoerper, QflA-11237 antikoerper, QtrA-10022 antikoerper, Sm-N antikoerper, SmN antikoerper, snRNP-N antikoerper, small nuclear ribonucleoprotein polypeptide-like antikoerper, small nuclear ribonucleoprotein polypeptides B and B1 antikoerper, small nuclear ribonucleoprotein polypeptide N antikoerper, small nuclear ribonucleoprotein N antikoerper, small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 antikoerper, SNRPN upstream reading frame antikoerper, Small nuclear ribonucleoprotein-associated protein N antikoerper, SNRPL antikoerper, snrpb antikoerper, SNRPN antikoerper, Snrpn antikoerper, snrpn antikoerper, SNURF antikoerper

Hintergrund: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy, mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.

Alias Symbols: SMN2, SMNC,

Protein Size: 294

Gen-ID: 6606

UniProt: Q16637