SNRPN Antikörper (N-Term)

Produktnummer ABIN3032638

Produktdetails anti-SNRPN Antikörper

Target: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNRPN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human SNRPN (FKAFDKHMNLILCDCDEF) was used as the immunogen for this SNRPN antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the SNRPN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the SNRPN antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu SNRPN

Target: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Andere Bezeichnung: SNRPN (SNRPN Produkte)

Synonyme: SNRB' antikoerper, SNRPB' antikoerper, Snrpn antikoerper, zgc:77315 antikoerper, HCERN3 antikoerper, PWCR antikoerper, RT-LI antikoerper, SM-D antikoerper, SMN antikoerper, SNRNP-N antikoerper, SNURF-SNRPN antikoerper, sm-N antikoerper, 2410045I01Rik antikoerper, Peg4 antikoerper, Pwcr1 antikoerper, FE 294 antikoerper, FE 294 psi antikoerper, FE294 antikoerper, FE294 psi antikoerper, SNURF antikoerper, SNRPN antikoerper, QflA-11237 antikoerper, QtrA-10022 antikoerper, Sm-N antikoerper, SmN antikoerper, snRNP-N antikoerper, small nuclear ribonucleoprotein polypeptide-like antikoerper, small nuclear ribonucleoprotein polypeptides B and B1 antikoerper, small nuclear ribonucleoprotein polypeptide N antikoerper, small nuclear ribonucleoprotein N antikoerper, small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 antikoerper, SNRPN upstream reading frame antikoerper, Small nuclear ribonucleoprotein-associated protein N antikoerper, SNRPL antikoerper, snrpb antikoerper, SNRPN antikoerper, Snrpn antikoerper, snrpn antikoerper, SNURF antikoerper

Hintergrund: Small Nuclear Ribonucleoprotein Polypeptide N, also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs(snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.

UniProt: P63162