MASP1 Antikörper (Middle Region)

Produktnummer ABIN5517538

Produktdetails anti-MASP1 Antikörper

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MASP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE

Produktmerkmale: This is a rabbit polyclonal antibody against MASP1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human MASP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MASP1

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Andere Bezeichnung: MASP1 (MASP1 Produkte)

Synonyme: AW048060 antikoerper, CCPII antikoerper, Crarf antikoerper, Masp1/3 antikoerper, 3MC1 antikoerper, CRARF antikoerper, CRARF1 antikoerper, MAP1 antikoerper, MASP antikoerper, MASP3 antikoerper, MAp44 antikoerper, PRSS5 antikoerper, RaRF antikoerper, mannan-binding lectin serine peptidase 1 antikoerper, mannan binding lectin serine peptidase 1 antikoerper, Masp1 antikoerper, MASP1 antikoerper

Hintergrund: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Alias Symbols: MASP1, CRARF, CRARF1, PRSS5,

Protein Interaction Partner: CDK19, CUL3, PDCD6IP, RPS6KA6, MAPK8IP2, NUDT21, NCK2, UFD1L, RPS6KA3, MAPK6, H2AFX, GSK3B, GADD45A, C2, SERPING1, FCN2, MBL2, C3, MASP2,

Protein Size: 380

Gen-ID: 5648

Pathways: Komplementsystem