DERL1 Antikörper (C-Term)

Produktnummer ABIN5515996

Produktdetails anti-DERL1 Antikörper

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DERL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: STPQFLYRWL PSRRGGVSGF GVPPASMRRA ADQNGGGGRH NWGQGFRLGD

Produktmerkmale: This is a rabbit polyclonal antibody against DERL1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human DERL1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Andere Bezeichnung: DERL1 (DERL1 Produkte)

Synonyme: CG10908 antikoerper, Dmel\\CG10908 antikoerper, DDBDRAFT_0188135 antikoerper, DDBDRAFT_0266772 antikoerper, DDB_0188135 antikoerper, DDB_0266772 antikoerper, MGC84200 antikoerper, wu:fb09d07 antikoerper, wu:fb94d05 antikoerper, wu:fj92g12 antikoerper, zgc:55637 antikoerper, 1110021N07Rik antikoerper, AI195141 antikoerper, AW551338 antikoerper, Derlin-1 antikoerper, derlin-1 antikoerper, DER-1 antikoerper, DER1 antikoerper, RGD1311835 antikoerper, DERLIN-1 antikoerper, F17A13.150 antikoerper, F17A13_150 antikoerper, Derlin-1 antikoerper, derlin-1 antikoerper, derlin-1.1 antikoerper, hypothetical protein antikoerper, Der1-like domain family, member 1 antikoerper, derlin 1 antikoerper, derlin 1 L homeolog antikoerper, DERLIN-1 antikoerper, Der-1 antikoerper, EDI_023440 antikoerper, PTRG_01331 antikoerper, derl1 antikoerper, DERL1 antikoerper, derl1.L antikoerper, Derl1 antikoerper, DER1 antikoerper

Hintergrund: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Alias Symbols: DERL1, DER1, UNQ243/PRO276,

Protein Interaction Partner: HM13, TCF25, XBP1, EGFR, USP19, ZFAND2B, Vcp, PTGS2, CAV1, SYVN1, DERL2, SHH, SEL1L, SERPINA1, FAF2, ALB, APP, DERL1, EDEM1, RNF5, RHO, NGLY1, BCAP31, CFTR, UBXN6, TRAM1, APOB, CLN6, UBXN4, ERN1, ASGR2, UBE2J1, ERLIN2, UBC, HLA-A, CACNA1C, YOD1, VIMP, KPN

Protein Size: 251

Gen-ID: 79139

NCBI Accession: NP_077271

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling