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DERL1 Antikörper (C-Term)

DERL1 Reaktivität: Human, Maus WB, IHC (p), FACS, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN453618
  • Target Alle DERL1 Antikörper anzeigen
    DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
    Bindungsspezifität
    • 15
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 222-251, C-Term
    Reaktivität
    • 38
    • 13
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 37
    • 1
    Kaninchen
    Klonalität
    • 37
    • 1
    Polyklonal
    Konjugat
    • 17
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DERL1 Antikörper ist unkonjugiert
    Applikation
    • 22
    • 16
    • 13
    • 13
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody recognizes Human and Mouse Derlin-1 at C-term. Other species not tested.
    Aufreinigung
    Protein A column, followed by peptide affinity purification
    Immunogen
    KLH conjugated synthetic peptide between 222~251 amino acids from the C-term region of Human Derlin-1 Genename: DERL1
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  • Applikationshinweise
    ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    DERL1 (Der1-Like Domain Family, Member 1 (DERL1))
    Andere Bezeichnung
    Derlin-1 (DERL1 Produkte)
    Synonyme
    CG10908 antikoerper, Dmel\\CG10908 antikoerper, DDBDRAFT_0188135 antikoerper, DDBDRAFT_0266772 antikoerper, DDB_0188135 antikoerper, DDB_0266772 antikoerper, MGC84200 antikoerper, wu:fb09d07 antikoerper, wu:fb94d05 antikoerper, wu:fj92g12 antikoerper, zgc:55637 antikoerper, 1110021N07Rik antikoerper, AI195141 antikoerper, AW551338 antikoerper, Derlin-1 antikoerper, derlin-1 antikoerper, DER-1 antikoerper, DER1 antikoerper, RGD1311835 antikoerper, DERLIN-1 antikoerper, F17A13.150 antikoerper, F17A13_150 antikoerper, Derlin-1 antikoerper, derlin-1 antikoerper, derlin-1.1 antikoerper, hypothetical protein antikoerper, Der1-like domain family, member 1 antikoerper, derlin 1 antikoerper, derlin 1 L homeolog antikoerper, DERLIN-1 antikoerper, Der-1 antikoerper, EDI_023440 antikoerper, PTRG_01331 antikoerper, derl1 antikoerper, DERL1 antikoerper, derl1.L antikoerper, Derl1 antikoerper, DER1 antikoerper
    Hintergrund
    Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.Synonyms: DER1, DERL1, DERtrin-1, Degradation in endoplasmic reticulum protein 1, Der1-like protein 1
    Gen-ID
    79139
    NCBI Accession
    NP_001128143
    UniProt
    Q9BUN8
    Pathways
    ER-Nucleus Signaling
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