RBM25 Antikörper (Middle Region)

Produktnummer ABIN5515107

Produktdetails anti-RBM25 Antikörper

Target: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RBM25 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DRDRTKERDR DRDRERDRDR DRERSSDRNK DRSRSREKSR DRERERERER

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RBM25

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RBM25

Target: RBM25 (RNA Binding Motif Protein 25 (RBM25))

Andere Bezeichnung: RBM25 (RBM25 Produkte)

Synonyme: fi03e10 antikoerper, zgc:56208 antikoerper, wu:fi03e10 antikoerper, si:ch211-105d18.5 antikoerper, rnpc7 antikoerper, s164 antikoerper, NET52 antikoerper, RED120 antikoerper, RNPC7 antikoerper, S164 antikoerper, Snu71 antikoerper, fSAP94 antikoerper, 2600011C06Rik antikoerper, 2610015J01Rik antikoerper, A130095G20Rik antikoerper, AI159652 antikoerper, AL023075 antikoerper, AU043498 antikoerper, RNA binding motif protein 25b antikoerper, RNA binding motif protein 25 antikoerper, RNA binding motif protein 25 S homeolog antikoerper, putative rna binding motif protein 25 antikoerper, rbm25b antikoerper, Rbm25 antikoerper, rbm25.S antikoerper, rbm25 antikoerper, RBM25 antikoerper, Smp_078610 antikoerper

Hintergrund: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure.

Alias Symbols: S164, NET52, RNPC7, Snu71, RED120, fSAP94

Protein Size: 843

Gen-ID: 58517

NCBI Accession: NM_021239, NP_067062

UniProt: P49756