MKRN1 Antikörper (C-Term)

Produktnummer ABIN5514960

Produktdetails anti-MKRN1 Antikörper

Target: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MKRN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SRYRAQRRNH FWELIEEREN SNPFDNDEEE VVTFELGEML LMLLAAGGDD

Produktmerkmale: This is a rabbit polyclonal antibody against MKRN1. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MKRN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MKRN1

Target: MKRN1 (Makorin Ring Finger Protein 1 (MKRN1))

Andere Bezeichnung: MKRN1 (MKRN1 Produkte)

Synonyme: MKRN1 antikoerper, MGC84269 antikoerper, mkrn1 antikoerper, Makorin-1 antikoerper, RNF61 antikoerper, RFP antikoerper, makorin ring finger protein 1 antikoerper, E3 ubiquitin-protein ligase makorin-1 antikoerper, makorin ring finger protein 1 S homeolog antikoerper, makorin, ring finger protein, 1 antikoerper, MKRN1 antikoerper, LOC100393879 antikoerper, mkrn1.S antikoerper, Mkrn1 antikoerper

Hintergrund: This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: RNF61

Protein Size: 482

Gen-ID: 23608

NCBI Accession: NP_038474

UniProt: Q9UHC7

Pathways: Chromatin Binding