MELK Antikörper (Middle Region)

Produktnummer ABIN5514940

Produktdetails anti-MELK Antikörper

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MELK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MEETPKRKGA KVFGSLERGL DKVITVLTRS KRKGSARDGP RRLKLHYNVT

Produktmerkmale: This is a rabbit polyclonal antibody against MELK. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human MELK

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MELK

Target: MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))

Andere Bezeichnung: MELK (MELK Produkte)

Synonyme: MELK antikoerper, xmelk antikoerper, Melk antikoerper, HPK38 antikoerper, AI327312 antikoerper, MPK38 antikoerper, mKIAA0175 antikoerper, fb71b01 antikoerper, fe01f04 antikoerper, wu:fb71b01 antikoerper, wu:fe01f04 antikoerper, maternal embryonic leucine zipper kinase antikoerper, maternal embryonic leucine zipper kinase L homeolog antikoerper, MELK antikoerper, melk antikoerper, cgd5_2270 antikoerper, Melk antikoerper, melk.L antikoerper

Hintergrund: MELK is a serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. It acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. And it plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. It may also play a role in primitive hematopoiesis.

Alias Symbols: MELK, KIAA0175,

Protein Interaction Partner: UBC, YGR054W, Acaca, CSN1S1, MELK, MBP, LMNB1, BABAM1, ZNF622, SF3B1, EIF2S1, CDC5L, PPP1R8, HIST1H1B, CDC25B,

Protein Size: 457

Gen-ID: 9833