FGFR4 Antikörper (Middle Region)

Produktnummer ABIN5514768

Produktdetails anti-FGFR4 Antikörper

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LITGDSLTSS NDDEDPKSHR DPSNRHSYPQ QAPYWTHPQR MEKKLHAVPA

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FGFR4

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Andere Bezeichnung: FGFR4 (FGFR4 Produkte)

Synonyme: FGFR4 antikoerper, XFGFR-4 antikoerper, XFGFR-4a antikoerper, cd334 antikoerper, fgfr-4 antikoerper, jtk2 antikoerper, tkf antikoerper, xfgfr4 antikoerper, CD334 antikoerper, JTK2 antikoerper, TKF antikoerper, Fgfr-4 antikoerper, etID309818.21 antikoerper, wu:fc13h10 antikoerper, zgc:111935 antikoerper, fgfr-4c antikoerper, fgfr4 antikoerper, fibroblast growth factor receptor 4 antikoerper, fibroblast growth factor receptor 4 S homeolog antikoerper, FGFR4 antikoerper, fgfr4 antikoerper, Fgfr4 antikoerper, fgfr4.S antikoerper

Hintergrund: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

Alias Symbols: TKF, JTK2, CD334

Protein Size: 762

Gen-ID: 2264

NCBI Accession: NM_001291980, NP_002002

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding