DIO2 Antikörper (Middle Region)

Produktnummer ABIN5514705

Produktdetails anti-DIO2 Antikörper

Target: DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ILLKHVVLLL SRSKSTRGEW RRMLTSEGLR CVWKSFLLDA YKQVKLGEDA

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DIO2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DIO2

Target: DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))

Andere Bezeichnung: DIO2 (DIO2 Produkte)

Synonyme: 5DII antikoerper, D2 antikoerper, DIOII antikoerper, SelY antikoerper, TXDI2 antikoerper, AI324267 antikoerper, Deio2 antikoerper, cb684 antikoerper, DIO2 antikoerper, dio2-A antikoerper, 5dii antikoerper, sely antikoerper, txdi2 antikoerper, iodothyronine deiodinase 2 antikoerper, deiodinase, iodothyronine, type II antikoerper, deiodinase, iodothyronine, type 2 L homeolog antikoerper, deiodinase, iodothyronine, type 2 antikoerper, type II iodothyronine deiodinase antikoerper, DIO2 antikoerper, Dio2 antikoerper, dio2 antikoerper, dio2.L antikoerper, LOC100861220 antikoerper

Hintergrund: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: D2, 5DII, SelY, DIOII, TXDI2,

Protein Size: 273

Gen-ID: 1734

NCBI Accession: NM_000793, NP_000784

UniProt: Q92813

Pathways: Hormone Transport, Hormone Activity