Presenilin 1 Antikörper (C-Term)

Produktnummer ABIN545739

Produktdetails anti-Presenilin 1 Antikörper

Target: Presenilin 1 (PSEN1)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Presenilin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.

Kreuzreaktivität: Human, Maus

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PSEN1.

Anwendungsinformationen

Applikationshinweise: ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-Presenilin 1 Antikörper (ABIN545739)

Miklossy, Taddei, Suva, Verdile, Fonte, Fisher, Gnjec, Ghika, Suard, Mehta, McLean, Masters, Brooks, Martins: "Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease." in: Neurobiology of aging, Vol. 24, Issue 5, pp. 655-62, (2003) (PubMed).

Kim, Ikeuchi, Yu, Sisodia: "Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 33992-4002, (2003) (PubMed).

Marambaud, Wen, Dutt, Shioi, Takashima, Siman, Robakis: "A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations." in: Cell, Vol. 114, Issue 5, pp. 635-45, (2003) (PubMed).

Details zu Presenilin 1

Target: Presenilin 1 (PSEN1)

Andere Bezeichnung: Presenilin-1 (PSEN1 Produkte)

Synonyme: pre1 antikoerper, psen antikoerper, zfPS1 antikoerper, zf-PS1 antikoerper, ad3 antikoerper, fad antikoerper, ps1 antikoerper, s182 antikoerper, X-PS-beta antikoerper, X-PS-alpha antikoerper, AD3 antikoerper, FAD antikoerper, PS-1 antikoerper, PS1 antikoerper, S182 antikoerper, Ad3h antikoerper, presenilin 1 antikoerper, presenilin 1 L homeolog antikoerper, psen1 antikoerper, PSEN1 antikoerper, Psen1 antikoerper, psen1.L antikoerper

Gen-ID: 5663

Pathways: Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport