Presenilin 1 Antikörper (PSEN1) (Middle Region)

Details for Product anti-PSEN1 Antibody No. ABIN2787886, Anbieter: Anmelden zum Anzeigen
Antigen
  • pre1
  • psen
  • zfPS1
  • zf-PS1
  • ad3
  • fad
  • ps1
  • s182
  • X-PS-beta
  • X-PS-alpha
  • AD3
  • FAD
  • PS-1
  • PS1
  • S182
  • Ad3h
  • presenilin 1
  • presenilin 1 L homeolog
  • psen1
  • PSEN1
  • Psen1
  • psen1.L
Epitop
Middle Region
76
41
36
18
17
14
9
9
9
6
4
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
263
171
160
31
19
19
8
8
6
6
3
2
2
1
1
1
Wirt
Kaninchen
220
60
18
17
4
2
Klonalität
Polyklonal
Konjugat
Dieser Presenilin 1 Antikörper ist unkonjugiert
14
14
12
7
7
6
5
5
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
251
121
102
42
39
30
27
14
11
7
5
3
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human PSEN1
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN982321.
Sequenz EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG
Homologie Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 85%
Produktmerkmale This is a rabbit polyclonal antibody against PSEN1. It was validated on Western Blot.
Reinigung Affinity Purified
Plasmids, Primers & others Plasmide, Primers & weitere Presenilin 1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung PSEN1 (PSEN1 Antibody Abstract)
Hintergrund Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Alias Symbols: AD3, FAD, PS1, S182, PS-1
Protein Interaction Partner: UBC, TRAF6, TGFBR1, ERLIN2, PSMB1, PSMA5, ETFA, TDP2, PSEN2, PSEN1, APH1B, PSENEN, APH1A, NCSTN, ITSN2, PDCD4, KANK2, EPB41L3, CDC37, TUBA1B, AP1M2, UMPS, PRDX2, ST13, SCN1A, RHEB, RAD23A, RAB3A, OXCT1, NOS3, NDUFS8, HMGB1, GCDH, GAPDH, FGF13, ENSA, DTNA,
Protein Size: 467
Molekulargewicht 53 kDa
Gen-ID 5663
NCBI Accession NM_000021, NP_000012
UniProt P49768
Pathways Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 467 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Presenilin 1 (PSEN1) (Middle Region) antibody (ABIN2787886) WB Suggested Anti-PSEN1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Immunohistochemistry (IHC) image for anti-Presenilin 1 (PSEN1) (Middle Region) antibody (ABIN2787886) Immunohistochemistry with Small intestine tissue at an antibody concentration of 5µg/...
Immunohistochemistry (IHC) image for anti-Presenilin 1 (PSEN1) (Middle Region) antibody (ABIN2787886) Small intestine
Western Blotting (WB) image for anti-Presenilin 1 (PSEN1) (Middle Region) antibody (ABIN2787886) Host: Rabbit
Target Name: PSEN1
Sample Tissue: Human Adult Placenta
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