Huntingtin Antikörper (pSer421)

Produktnummer ABIN538469

Produktdetails anti-Huntingtin Antikörper

Target: Huntingtin (HTT)

Bindungsspezifität: pSer421

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Huntingtin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Verwendungszweck: Rabbit polyclonal antibody raised against synthetic phosphopeptide of HTT.

Spezifität: This antibody is specific to phosphorylated human Huntingtin protein at the pS421 residue. Minimal reactivity isexpected with the non-phosphorylated form of the protein.

Kreuzreaktivität: Huhn, Schimpanse, Human, Schwein

Produktmerkmale: Antibody Reactive Against Synthetic Peptide.

Immunogen: Synthetic phosphopeptide corresponding to residues surrounding S421 of human HTT.

Anwendungsinformationen

Applikationshinweise: ELISA (1:10000-1:40000)
Western Blot (1:500-1:3000)
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 20 mM KH₂PO₄, 150 mM NaCl, pH 7.2 (0.01 % sodium azide)

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-Huntingtin Antikörper (ABIN538469)

Lee, Yoshihara, Littleton: "Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 9, pp. 3224-9, (2004) (PubMed).

Zainelli, Ross, Troncoso, Fitzgerald, Muma: "Calmodulin regulates transglutaminase 2 cross-linking of huntingtin." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 8, pp. 1954-61, (2004) (PubMed).

Trushina, Dyer, Badger, Ure, Eide, Tran, Vrieze, Legendre-Guillemin, McPherson, Mandavilli, Van Houten, Zeitlin, McNiven, Aebersold, Hayden, Parisi, Seeberg, Dragatsis, Doyle, Bender, Chacko, McMurray: "Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro." in: Molecular and cellular biology, Vol. 24, Issue 18, pp. 8195-209, (2004) (PubMed).

Details zu Huntingtin

Target: Huntingtin (HTT)

Andere Bezeichnung: Huntingtin (HTT Produkte)

Synonyme: HTT antikoerper, hd antikoerper, ZHD antikoerper, CG9995 antikoerper, Dmel\\CG9995 antikoerper, HD antikoerper, Hsap\\HD antikoerper, Htt antikoerper, dHtt antikoerper, dhtt antikoerper, SLC6A4 antikoerper, huntington antikoerper, it15 antikoerper, htt antikoerper, IT15 antikoerper, AI256365 antikoerper, C430023I11Rik antikoerper, Hd antikoerper, Hdh antikoerper, huntingtin antikoerper, HTT antikoerper, htt antikoerper, LOC373520 antikoerper, Htt antikoerper

Gen-ID: 3064

Pathways: PI3K-Akt Signalweg, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport