SCNN1B Antikörper (AA 617-638) (PE)

Produktnummer ABIN5066891

Produktdetails anti-SCNN1B Antikörper (PE)

Target: SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))

Bindungsspezifität: AA 617-638

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCNN1B Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Detects ~87 kDa.

Kreuzreaktivität: Maus

Aufreinigung: Protein G Purified

Immunogen: Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617-638)

Klon: 7B8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• IHC (1:150)
• optimal dilutions for assays should be determined by the user.

Kommentare:

A 1:1000 dilution of ABIN5066891 was sufficient for detection of ENaC beta in 15 μg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu SCNN1B

Target: SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))

Andere Bezeichnung: ENaC beta (SCNN1B Produkte)

Synonyme: BESC1 antikoerper, ENaCb antikoerper, ENaCbeta antikoerper, SCNEB antikoerper, RNENACB antikoerper, besc1 antikoerper, betaxENaC antikoerper, enacb antikoerper, enacbeta antikoerper, scnn1b antikoerper, beta-ENaC antikoerper, scneb antikoerper, SCNN1B antikoerper, BETA-ENAC antikoerper, sodium channel epithelial 1 beta subunit antikoerper, sodium channel, non voltage gated 1 beta subunit L homeolog antikoerper, sodium channel, non voltage gated 1 beta subunit antikoerper, sodium channel, nonvoltage-gated 1 beta antikoerper, sodium channel, non voltage gated 1 beta subunit S homeolog antikoerper, SCNN1B antikoerper, Scnn1b antikoerper, scnn1b.L antikoerper, scnn1b antikoerper, scnn1b.S antikoerper

Hintergrund: The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).

Gen-ID: 24767

NCBI Accession: NP_036780

UniProt: P37090