SOX10 Antikörper (AA 115-269)

Produktnummer ABIN5027534

Produktdetails anti-SOX10 Antikörper

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Bindungsspezifität: AA 115-269

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOX10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant SOX-10 protein (amino acids 115-269) was used as the immunogen for this antibody.

Klon: ABM4E24

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu SOX10

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Andere Bezeichnung: SOX10 (SOX10 Produkte)

Synonyme: DOM antikoerper, PCWH antikoerper, WS2E antikoerper, WS4 antikoerper, WS4C antikoerper, SOX-10 antikoerper, SOX10 antikoerper, dom antikoerper, ws4 antikoerper, Dom antikoerper, Sox21 antikoerper, SOX9 antikoerper, cls/sox10 antikoerper, zgc:100757 antikoerper, SRY-box 10 antikoerper, SRY box 10 antikoerper, SRY-box 10 L homeolog antikoerper, SRY (sex determining region Y)-box 10 antikoerper, SOX10 antikoerper, Sox10 antikoerper, sox10.L antikoerper, sox10 antikoerper

Hintergrund: SOX10 is a transcription factor that belongs to the high mobility group (HMG) box super family of DNA-binding proteins. It is located at 22q13.1 and is highly conserved in vertebrates. SOX10 is expressed in many different cell types and tissues and implicated in neural crest development, nervous system neurogenesis, as well as differentiation of oligodendrocyte, glia and melanocytes. It modulates other transcription factors including PAX3 forming a complex and acts as a nucleocytoplasmic shuttle protein in neural crest and oligodendrocyte development. The level of expression of SOX10 plays pivotal regulatory role both in tumor progression and suppression. Its elevated expression, possess tumor-promoting activities in several malignancies including melanoma and gliomas. Decreased expression of SOX10 promotes tumor cell growth and focal adhesions of Merlin-null schwannoma cells. SOX10 may also function as a tumor suppressor by inducing tumor cell apoptosis, inhibiting invasion, regulating cell EMT and stemness through suppressing Wnt/Beta-catenin signaling. Mutations of the Sox10 gene are known to cause various combinations of hearing loss and pigmentation defects in humans such as Waardenburg syndrome, a rare auditory-pigmentary disorder that generates varying combinations of hearing loss and pigmentation defects.

Molekulargewicht: 50 kDa

Gen-ID: 6663

UniProt: P56693

Pathways: Chromatin Binding