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PD-L1 Antikörper (AA 13-224)
PD-L1
Reaktivität: Human
WB, FACS, IHC
Wirt: Maus
Monoclonal
ABM5F25
unconjugated
Produktnummer ABIN5027498
Produktdetails anti-PD-L1 Antikörper
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Target
Alle PD-L1 Antikörper anzeigen
PD-L1
(CD274 (PD-L1))
Bindungsspezifität
Alle Epitope für PD-L1 Antikörper
AA 13-224
Reaktivität
Alle Reaktivitäten für PD-L1 Antikörper
Human
Wirt
Alle Wirte für PD-L1 Antikörper
Maus
Klonalität
Alle Klonalitäten für PD-L1 Antikörper
Monoklonal
Konjugat
Alle Konjugate für PD-L1 Antikörper
Dieser PD-L1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für PD-L1 Antikörper
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
Aufreinigung
Protein G Chromatography
Immunogen
A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen for this antibody.
Klon
ABM5F25
Isotyp
IgG2b kappa
Top Product
Discover our top product PD-L1 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
FACS: 0.5-1 μg/10^6 cells, WB: 2-4 μg/mL, IHC: 5-10 μg/mL
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Referenzen für anti-PD-L1 Antikörper (ABIN5027498)
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Faruk, Ibrahim, Aminu, Adamu, Abdullahi, Suleiman, Rafindadi, Mohammed, Iliyasu, Idoko, Saidu, Randawa, Musa, Ntekim, Shah, Abubakar, Adoke, Manko, Awasum : "Prognostic significance of BIRC7/Livin, Bcl-2, p53, Annexin V, PD-L1, DARC, MSH2 and PMS2 in colorectal cancer treated with FOLFOX chemotherapy with or without aspirin. " in: PLoS ONE , Vol. 16 , Issue 1 , pp. e0245581 , (2021 ) (PubMed ).
Details zu PD-L1
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Target
PD-L1
(CD274 (PD-L1))
Andere Bezeichnung
PDL-1 (PD-L1 Produkte )
Synonyme
B7-H antikoerper, B7H1 antikoerper, PD-L1 antikoerper, PDCD1L1 antikoerper, PDCD1LG1 antikoerper, PDL1 antikoerper, A530045L16Rik antikoerper, B7h1 antikoerper, Pdcd1l1 antikoerper, Pdcd1lg1 antikoerper, Pdl1 antikoerper, RGD1566211 antikoerper, CD274 molecule antikoerper, CD274 antigen antikoerper, programmed cell death 1 ligand 2 antikoerper, CD274 antikoerper, Cd274 antikoerper, PDCD1LG2 antikoerper
Hintergrund
PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belongs to the B7 superfamily that inhibits immune responses through its receptor, PD-1 and PD-L1 play a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation and in numerous autoimmune diseases.
Molekulargewicht
44 kDa
Gen-ID
29126
UniProt
Q9NZQ7
Pathways
Cancer Immune Checkpoints
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