SMARCB1 Antikörper (AA 11-231)

Produktnummer ABIN5027323

Produktdetails anti-SMARCB1 Antikörper

Target: SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))

Bindungsspezifität: AA 11-231

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMARCB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant INI-1/SNF5 protein (amino acids 11-231) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu SMARCB1

Target: SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))

Andere Bezeichnung: INI-1/SNF5 (SMARCB1 Produkte)

Synonyme: SMARCB1 antikoerper, BAF47 antikoerper, INI1 antikoerper, MRD15 antikoerper, RDT antikoerper, RTPS1 antikoerper, SNF5 antikoerper, SNF5L1 antikoerper, Sfh1p antikoerper, Snr1 antikoerper, hSNFS antikoerper, AU020204 antikoerper, Baf47 antikoerper, Ini1 antikoerper, SNF5/INI1 antikoerper, Snf5 antikoerper, fc51b01 antikoerper, smarcb1 antikoerper, wu:fc51b01 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 S homeolog antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b antikoerper, SMARCB1 antikoerper, Smarcb1 antikoerper, smarcb1.S antikoerper, smarcb1b antikoerper

Hintergrund: SNF5/INI1 is the core subunit of the SWI/SNF chromatin remodeling complex that contributes to the regulation of chromatin structure. It is a tumor suppressor in humans and mice, with an essential role in early embryonic development. SNF5 interacts with UV damage recognition factor XPC and colocalizes at the damage site upon UV irradiation. Inactivation of SNF5 affects the recruitment of ATM checkpoint kinase to the damage site and ATM activation by phosphorylation. SNF5 deficiency results in a defect in H2AX and BRCA1 phosphorylation at the damage site. SNF5/INI1 forms a functional complex with p300/GATA4 on hypertrophic response gene promoters in cardiomyocytes. It plays an inhibitory role in cardiomyocyte hypertrophy by suppressing p300/GATA4-dependent transcription. SNF5 genetic mutations were first reported in malignant rhabdoid tumors.

Molekulargewicht: 40 kDa

Gen-ID: 6598

UniProt: Q12824