SMARCB1 Antikörper (AA 86-385)

Produktnummer ABIN7171070

Produktdetails anti-SMARCB1 Antikörper

Target: SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))

Bindungsspezifität: AA 86-385

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMARCB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 protein (86-385AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SMARCB1

Target: SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))

Andere Bezeichnung: SMARCB1 (SMARCB1 Produkte)

Synonyme: SMARCB1 antikoerper, BAF47 antikoerper, INI1 antikoerper, MRD15 antikoerper, RDT antikoerper, RTPS1 antikoerper, SNF5 antikoerper, SNF5L1 antikoerper, Sfh1p antikoerper, Snr1 antikoerper, hSNFS antikoerper, AU020204 antikoerper, Baf47 antikoerper, Ini1 antikoerper, SNF5/INI1 antikoerper, Snf5 antikoerper, fc51b01 antikoerper, smarcb1 antikoerper, wu:fc51b01 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 S homeolog antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b antikoerper, SMARCB1 antikoerper, Smarcb1 antikoerper, smarcb1.S antikoerper, smarcb1b antikoerper

Hintergrund:

Background: Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Aliases: BAF47 antibody, BRG1-associated factor 47 antibody, hSNF5 antibody, INI1 antibody, Integrase interactor 1 protein antibody, Malignant rhabdoid tumor suppressor antibody, RDT antibody, RTPS1 antibody, Sfh1p antibody, SMARCB1 antibody, SNF5 homolog antibody, SNF5_HUMAN antibody, SNF5L1 antibody, Snr1 antibody, Sucrose nonfermenting yeast homolog like 1 antibody, SWI/SNF complex component SNF5 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 antibody, SWI10 antibody, Transcription factor TYE4 antibody, Transcription regulatory protein SNF5 antibody, TYE4 antibody

UniProt: Q12824